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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Development Of Immune Structures Of The Leaning Intestine Of Rabbits In Early Postnatal Ontogenesis

Author: FIRDAVS ORIPOV, SOPHIA BLINOVA, TASHPULAT DEKHKANOV, SALIM DAVLATOV
Abstract: Relevance. The immune response to gut antigens is initiated in the organized gut-associated lymphoid tissue, which regulates its specificity and modulates the gut microbiota. The study of the development of immune structures in early postnatal ontogenesis will make it possible to induce a sequence of their emergence in milk feeding. The aim of the study was to identify the features of the development of immune structures in the jejunum in newborn rabbits and during the period of milk feeding. Materials and methods. Morphological and morphometric methods were used to study the immune structures of the jejunum in 12 animals during the period of newborn and milk feeding (10 days after birth). Paraffin sections were stained using general histological methods. On a certain area of the field of view of the microscope, all types of lymphocytes, cellular elements of the mucous membrane were counted, and their ratio was determined. Research results. Afferent immune structures of the jejunal mucosa in newborn animals are represented by accumulations of lymphoid tissue without a definite shape, they are indistinctly limited from the surrounding connective tissue of the lamina propria, there are no structural and functional zones characteristic of lymph nodules. During the period of milk feeding, efferent immune structures are determined in the stroma of the villi and crypts, while the number of diffusely located lymphocytes and lymphoblasts increases sharply, lymphocytes are also found between epithelial cells. Conclusions. Morphological signs show that in postnatal ontogenesis there is an earlier development of the afferent link of immunogenesis in the jejunum of rabbits compared to the efferent one.
Keyword: jejunum, immune structures, postnatal ontogenesis.
DOI: https://doi.org/10.31838/ijpr/2021.13.01.042
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