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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Differential Diagnosis of Lymphadenopathies

Author: SEIDALIN N.K, BENBERIN V.V, SHANAZAROV N.A, TULEUBAEVA A.A, SATAEVA ?.S, TOKHPANOVA N.A, ISABEKOVA A.M
Abstract: Purpose of research: To conduct a systematic analysis of data from various literature sources on the differential diagnosis of lymph node lesions. Materials and methods. A review of the literature in the Cochrane Library, Elibrary, PubMed systems for 20 years, which deals with the diagnosis of lymph node lesions. Results: Data analysis shows that in routine clinical practice, immunohistochemical tests and other auxiliary methods such as flow cytometry, cytogenetic and molecular biological methods are used to establish the diagnosis of lymph node lesions. Through the use of these methodologies, significant progress has been made in pathologic diagnosis. However, the diagnosis of lymphadenopathies in some cases is still very difficult. More than ten percent of cases of annual consultations of pathologists and cytologists are biomaterials of patients with lymph node lesions in lymph-proliferative, oncological and infectious processes, which reflects the complexity of this area. Conclusion: the method of conducting an immunocytochemical study using test systems in the format of cellular biochips allows reducing the invasiveness of biomaterial sampling, reducing the time from material sampling to making a morphological diagnosis indicating the tumor subtype, and eliminating dependence on the method of material sampling.
Keyword: lymphoma, immunocytochemistry, immunohistochemistry, biochip, lymph node metastases
DOI: https://doi.org/10.31838/ijpr/2020.12.04.411
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