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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Qualitative Analysis and In-Vitro Anthelmintic Evaluation of Cleome Gynandra Stem

Author: ANANDARAJAGOPAL KALUSALINGAM, NASYIKA SAMSUDIN, ABDULLAH KHAN, KRUPAVARAM BETHALLA, VIJAY KOTRA, KAI BIN LIEW, MEI JUN LOY, SIEW MEI YEE
Abstract: Plants and their extracts play a major role as the choices of treatment due its medicinal value that might be due to the presence of various phytochemicals. Traditionally used medicinal plants can be studied for a wide range of perspectives to find new chemical entities for the treatment of chronic as well as acute diseases. In treating parasitic diseases such as internal helminth infections, medicinal plants possess a significant role and efficacy. Cleome gynandra (family: Cleomaceae) commonly known as Mamang in Malay language is one of the important medicinal plants in Malaysia. In Ayurvedic medicine, C. gynandra is believed to act as anthelmintic and used to treat other gastrointestinal disorders. There are several studies that reveal the anthelmintic activity exhibited by leaves and seeds of C. gynandra. The present study was aimed to determine the phytoconstiuents and evaluate the anthelmintic potential of Cleome gynandra stem extracts. Ethanol and water extracts of C. gynandra stem were obtained by cold maceration method and performed qualitative phytochemical analysis. Anthelmintic activity of the extracts (25, 50 and 100 mg/ml) was investigated against earthworms, Pheretima posthuma by determining the time taken to paralyse and death of earthworm compared to albendazole (20 mg/ml). Both extracts (50 and 100 mg/ml) of C. gynandra exhibited dose dependent anthelmintic activity however, water extract exhibited more activity as compared to ethanol extract.
Keyword: Cleome gynandra, earthworm, Pheretima posthuma, anthelmintic.
DOI: https://doi.org/10.31838/ijpr/2021.13.01.034
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0.12
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