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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Metformin and Its Use in Cancer Therapy

Author: MEGHANADH MANYAM, RAKSHITH K, SAHYADRI M, SAMUEL GEORGE P
Abstract: The drug of choice in the first line treatment of type II diabetes mellitus is the biguanide, metformin. It has demonstrated the proof of expanding constructive outcomes in malignancy treatment. Diminished occurrence of malignant growth in the metformin treatment bunch just as abatement insulin opposition which in a roundabout way controls insulin level was appeared by a few epidemiological examinations. The adequacy of metformin in malignant growth chemopreventive activity has finished up noteworthy outcomes in different organ diseases like bosom, colon and prostate tumors. There is a direct antitumor impact of metformin contemplated in vivo and in vitro demonstrates that it discourages tumor multiplication and discards the autophagy, apoptosis and cell cycle capture of tumor cells. The essential protein in unsaturated fat biosynthesis is unsaturated fat synthase which may likewise be interceded by guideline of unsaturated fat combination subject to AMPK actuation by metformin in malignant growth treatment. The decrease in amalgamation of professional provocative cytokines impacted by AMPK actuation in different cell types. There are a few Clinical preliminaries including metformin as exploratory medication in disease patients and a few information demonstrates factually beneficial outcome of metformin in oncology. This survey essentially focuses on the theory of metformin activity in disease cells, in its treatment and on late advancement in clinical preliminaries.
Keyword: Metformin, Cancer Therapy, Diabetes, AMPK, Clinical Evidence
DOI: https://doi.org/10.31838/ijpr/2021.13.01.033
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0.12
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