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Acute and Subacute (28-Day) Toxicity Assessment of Ethanolic Extract of Seeds of Asteracantha longifolia Nees (Linn)
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| Author:
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MANIVANNAN.E , KOTHAI.R, ARUL.B
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| Abstract:
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Asteracantha longifolia (Linn.) is a small herb also known as Hygrophila auriculata belongs to the family Acanthaceae. It is one of the important medicinal plants used in ayurvedic and Unani medicine. The various parts of the plant have been extensively used in traditional medicine for various diseases. The present study was planned to investigate the toxicity effects of ethanolic extracts seeds of Asteracantha longifolia to assess its safety. The toxicity studies were performed as per OECD (Organisation for Economic Co-operation and Development) – Guidelines 423 and 407. In an acute toxicity study, the animals were treated with single oral administration of ethanolic extracts of seeds of Asteracantha longifolia at the doses of 5, 50, 300 and 2000mg/kg and were observed for 14 days. In the Subacute toxicity study, the animals (male and female) were treated with extracts at the doses of 100, 200, 400 mg/kg orally for 28 days. The animals were observed weekly for any changes in general behaviour, body weights, food intake, water intake, and signs of morbidity and mortality. No signs of morbidity and mortality were observed during the 14 days acute toxicity study. Similarly, in sub-acute toxicity studies, the extract does not show any significant changes in body weight, food, and water intake, haematological, biochemical, and histopathological studies. No mortality was observed during the 28 days study. The results of the present study indicate that the oral administration of this extract does not show any toxicity in both acute and subacute toxicity studies. Hence, it was safer and non -toxic to rats, and further studies are required in animals and humans to confirm its therapeutic efficacy.
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| Keyword:
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Asteracantha longifolia, Acute toxicity, Sub-acute toxicity, Bio-chemical parameters, Haematological parameters.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.404
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| Download:
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