IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Formulation Development and Optimization of Extended Release Pellets of Dexketoprofen Trometamol

Author: BHUPENDRA G.PRAJAPATI, ALPESH PATEL
Abstract: The aim is to prepare extended release multi-particulates dosage form of Dexketoprofen trometamol which is the pharmacologically active isomer of ketoprofen. Utilization of active enantiomer with minimal dose and administration frequency, extended release multi-particulates dosage form is explored. Drug loaded pellets were prepared by Extrusion spheronization technique while extended release coating of these drug pellets were done by wurster coating process. Lactose and Microcrystalline cellulose as diluents, glycerin as plasticizer and Povidone as binder were selected during drug loaded pellets development by extrusion-spheronization. Kollicoat SR 30D was used as sustained release polymer during extended release coating by wurster coating process. Triethyl citrate and Talc were used as plasticizer and anti-adherent during extended release coating process respectively. Wurster coating process parameters for sustained release were further statistically optimized for agglomerates formation, process efficiency and drug release profile using central composite design (CCD). Results shows that 1.0 to 1.2 bar atomisation air pressure, 7.8 to 10.0 gm/min spray rate and 29-34°C product bed temperature gave desired drug product quality attributes. Extended release multi-particulates were successfully developed for dexketoprofen trometamol which may be explore to manufacture various dosage forms like capsules, compressed tablets, pellets in sachet for ease of patient administration.
Keyword: Dexketoprofen Trometamol, pellets, Extrusion-spheronization, Fluid Bed Technology
DOI: https://doi.org/10.31838/ijpr/2021.13.01.016
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
SCImago Journal & Country Rank

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free