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Cobalamin and Methylmalonic Acid as Biomarkers of Vitamin B12 Deficiency in Elderly
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| Author:
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PUSPARINI , ALVINA, LIE TANU MERIJANTI, MEIYANTI
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| Abstract:
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Cobalamin as surrogate biomarker of vitamin B12 has various limitations. There are several other markers that can be used to determine the vitamin B12 concentration in the body, such as methylmalonic acid (MMA). The objective of this study was to determine the prevalence of vitamin B12 deficiency using appropriate cut-off levels of cobalamin and MMA and to determine the relationship between cobalamin and MMA as biomarkers of vitamin B12 deficiency in the elderly. This study was of cross-sectional design and was performed on 80 elderly women aged 60-75 years, from January to April 2019. All subjects were asked to fill in a questionnaire, then the subjects meeting the inclusion and exclusion criteria underwent examination for anthropometric measures, vital signs, dietary recall, food frequency for vitamin B12, serum MMA and cobalamin. Data analysis was carried out with inter-quartile one-way Anova and the Spearman test between MMA and cobalamin concentrations, at level of significance p of < 0.05. The prevalence of B12 deficiency based on cobalamin was 8.75%, whereas the prevalence based on MMA was 72.3 %. The MMA concentration did not decrease consistently with increasing inter-quartile cobalamin concentration. The results of the Spearman test showed a low negative correlation between cobalamin and MMA, with r = -0.233 and p<0.043. In conclusion, the prevalence of B12 deficiency based on the MMA concentration was higher than that based on the cobalamin concentration. There was a weak negative correlation between cobalamin and MMA concentrations.
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| Keyword:
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Methylmalonic acid, MMA, cobalamin, elderly, vitamin B12 deficiency
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.376
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| Download:
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