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Fabrication of novel topical drug loaded elastic membrane vesicles of liposomes as a tool for dermal delivery in effective treatment of psoriasis
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| Author:
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S.NAGALAKSHMI , V. NIVATHRA, S. SHANMUGANATHAN
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| Abstract:
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The psoriasis is an immunologically mediated disease caused by activation of T lymphocytes in dermis and epidermis. The passive target of thin elastic membrane vesicles of liposomes once combined with the drug is used for the effective treatment of psoriasis by dermal delivery and also useful for the treatment of antifungal and antibacterial therapy. The objective of this study was to develop the vesicles of liposomes with a suitable lipid layer and to evaluate the developed liposomal dispersion for its characterization studies. The present study involves the preparation and characterization of the stable thin film elastic membrane vesicles of liposomes containing salicylic acid as a drug. The characterization studies were implemented for FTIR studies, drug content, pH, vesicle morphology, entrapment efficiency, and in-vitro release studies. The formulation was optimized based on in-vitro release studies and encapsulation efficiency. The optimized liposomal formulation was converted into a gel using a suitable gelling agent like HMPC, carbopol, PEG and the characterization were done. It would be a promising drug delivery system for the effective treatment of psoriasis
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| Keyword:
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Liposomes, dispersion, characterization, efficacy, in-vitro release,
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.367
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| Download:
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