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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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The Correlation between Homocysteine and Bone Mineral Density by Terminal C – Telopeptide Crosslink Serum Test on Post – Menopausal Women

Author: IRMIYA RACHMIYANI, YUDHISMAN IMRAN, DONNA ADRIANI, LILY M SURJADI, RULLY AYU NIRMALASARI, TUBAGUS FERDI FADILLAH
Abstract: Bone is a very active organ. It is a continuous process called bone remodeling involving resorption (osteoclastic activity) and constant formation (osteoblastic activity). Blood homocysteine level has a close relation with fracture risk due to its impact to bone quantity and quality. Bone mineral density can be recognized by c-terminal telopeptide crosslink serum (CTX) on post menopause woman. Research Objective: to discover relation between homocysteine level and bone mineral density by c-terminal telopeptide crosslink serum (CTX) test on post menopause. This research is cross sectional study on post menopause woman at Mampang Jakarta Public Health Centre. Subject is provided by questionnaire containing inclusion and exclusion, conducted physical examination (age, weight, height, systolic and diastolic blood pressure) and laboratory test consisting of fasting blood sugar level, homocysteine and CTX serum. Average age is between 65.07 and 3.09 years old, average body mass index is between 26.01 and 3.26, average systolic blood pressure is between 129,23 and 22,04 mmHg, and average diastolic blood pressure is between 79.93 and 12.03 mmHg. Average homocysteine level is between 11.94 and 2.47, average CTx is between 0.56 and 0.13. There is a significant relation between homocysteine level and Ctx (p=0,013) and correlation (r=0.37).
Keyword: Homocysteine, Bone Mineral Density, Post Menopause Woman, CTX Serum
DOI: https://doi.org/10.31838/ijpr/2020.12.04.364
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