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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Comparison between Effect of Fenitoin and Valproic Acid on Total Cholesterol in Epilepsy

Author: FARISA AULIA, YUDHISMAN IMRAN
Abstract: The use Anti Epilepsy Drugs (OAE) drugs for a long time can cause side effects, one of the examples is an increase in total cholesterol levels. Phenytoin and Valproic Acid are examples of OAE drugs which can cause an increase in total cholesterol levels. The purpose of this study was to determine the difference in average total cholesterol in epilepsy patients with single phenytoin therapy and epilepsy patients with single treatment of valproic acid. This research design uses a cross-sectional study. Type of research is observational analytic. Retrieval of data obtained from medical records at the Bhayangkara Grade I Raden Said Sukanto Hospital and measurement of total fasting cholesterol levels. Data analysis was performed univariate and bivariate using the unpaired t-test. The prevalence of an increase in total cholesterol levels in epilepsy patients is 47.5%. There was a significant difference in total cholesterol in the phenytoin monotherapy group and valproic acid monotherapy group. Total cholesterol mean in patients with phenytoin monotherapy is higher by 27.8 mg/dl than the mean valproic acid monotherapy. There were no significant differences in the total cholesterol in female and male epilepsy patients. There was no significant difference in total cholesterol in epilepsy patients with duration of therapy =6 months and > 6 months. The mean total cholesterol in epilepsy patients with phenytoin monotherapy is higher than epilepsy patients with valproate acid monotherapy.
Keyword: Epilepsy, Phenitoin, Valproic Acid, Total Cholesterol
DOI: https://doi.org/10.31838/ijpr/2020.12.04.361
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