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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Clinical impact of antibiotic sensitivity in patients afflicted with diabetic foot ulcer

Author: , DENLIA TINTU ALEX, NAZIYA NAVAS, SAMBATH KUMAR.R, SUMITHA S.K.
Abstract: Diabetic Foot Infections are ruled as the major complication of Diabetes Mellitus which ultimately results in amputations and associate with greater morbidity and mortality. Appropriate choice of antibiotics andidentification of microbial flora have boundless role in providing optimal therapy to the patients. This study was conducted in a secondary care hospital in South India to spot-out bacteriology and antibiotic sensitivity pattern among patients afflicted with Diabetic Foot Infection. Methods: The Prospective Observational study was carried out for a period of six months from January 2019 to June 2019. Pus swabs were collected aseptically from 169 patients, whom were clinically suspected of infected diabetic wounds. Bacterial isolates were identified by standard methods and undergone antibiotic susceptibility test. Results: Among 169 patients 56.80% were males and 43.19% were females: mean age was 64 ± 18.71years. Sole was found to be the major site of ulcer (31.95%) and Grade III ulceration (41.42) was predominant. Total eight organisms were isolated, in which Staphylococcus aureus44(39.28%) was the most frequent and Meropenem was the antibiotic that showed highest susceptibility rates for the entire organisms. Conclusion: The prevalence of S aureusin this hospital setting was found to be high. The high level of sensitivity was observed to Meropenem and Gentamicin. Appropriate antimicrobial therapy according to susceptibility pattern would reduce further complications and multidrug resistance in diabetic foot ulcer patients.
Keyword: Antibiotic, Foot Ulcer, Micro-organism, Resistance, Sensitivity.
DOI: https://doi.org/10.31838/ijpr/2020.12.04.357
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