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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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HPV 52 most dominant Human Papillomavirus (HPV) genotype in women infected by Human Immunodeficiency Virus (HIV) that get antiretroviral treatment (ART)

Author: RISNAWATI , ARIAWAN SOEJOENOES, SUHARYO HADISAPUTRO, MUCHLIS AU SOFRO, SAMSURIDJAL DJAUZI, NOOR PRAMONO, ARI SUWONDO, DENDI DURAHMAN, JULIAN PRATAMA
Abstract: Background:: the persistence of oncogenic or high-risk HPV infection (HPV-RT) is a causative agent of cervical cancer, a cancer with the highest prevalence in Indonesia. HIV-infected women have a higher prevalence of RT-HPV infection than HIV-uninfected women. The aim of the study was to assess the distribution of HPV genotypes in HIV-infected women who received ART. Methods:: Analytical, cross-sectional study of 55 HIV-infected women between December 2019-March 2020 aged 24-51 years at the Dr. Kariadi Semarang and Salatiga City Hospital. HPV genotype examination method used Reserve Dot Blot "Flow-Trough" Hybridization method Results:: HPV DNA was detected 53%. Four samples (5.1%) could not be further categorized. 50% of respondents detected the HPV-RT genotype. The most common HPV-RT genotypes were HPV52 (7.7%), HPV68 (6.3%), and HPV66 (5.1%), whereas for low risk HPV genotypes (HPV-RR) which frequently appeared were HPV43 (6.3%), HPV44 (6.3%), and HPV6 (5.1%). Conclusions:: the results of this study indicate the diversity of HPV genotypes in HIV-infected women and the most dominant genotype is HPV52.
Keyword: high risk HPV, low risk HPV, genotype, HIV infected women
DOI: https://doi.org/10.31838/ijpr/2020.12.04.355
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