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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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The Relation Between Fibroblast Growth Factor 21 and Oxidative Stress in Insulin Resistance With Diabetics

Author: SAFAA SABAH, THIKRA ALI ALLWASH
Abstract: Fibroblast Growth Factor 21(FGF21) has a key role in glucose and lipid metabolism and energy balance, as well as regulator of the oxidative stress cell response. The research included a study of oxidative stress in healthy and insulin resistance with diabetics also the relation between (FGF21) hormone and Oxidative Stress. The results showed increase FGF21 level in insulin resistance with diabetics type II (IR with DMT2) group as compare with its level with healthy control group, also significantly increase the level of fasting glucose, insulin, homeostasis model for insulin resistance (HOMA-IR), Triglycerides, Total cholesterol, Malondialdehyde (MDA) and the activity of Lactoperoxidase and peroxidase while there was a significantly decrease the activity of Aryl esterase . Also the results elucidated FGF21 level has positive correlation with peroxidase, loctoperoxidase enzymes and MDA, Triglycerides, Glucose, insulin, HOMA-IR, Total cholesterol, while FGF21 level shows significantly negative correlation with the activity of aryl esterase enzyme. It was concluded this study show the serum FGF21 level was significantly correlated with clinical parameter and oxidative stress in insulin resistance with diabetics type II and the identification of relation between FGF21 level and oxidative stress through the complications that occur in insulin resistance and diabetes mellitus type II patients.
Keyword: Fibroblast growth Factor21, Insulin resistance, diabetics type II, Oxidative stress, MDA, Triglycerides.
DOI: https://doi.org/10.31838/ijpr/2020.12.04.351
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