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The effects of irisin on the transforming growth factor-beta1(TGF-ß1) level in type-1 diabetic patients in Thi-Qar province.
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| Author:
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SAAD H.AL-BADRY, ALI A. AL-KHUZAIY, SHAYMAA A. KHALAF, ALI B. ROOMI
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| Abstract:
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The present study aimed at an assessment of irisin level in patients with the newly onset type 1diabetes mellitus" (T1DM) and their effects on the transforming growth factor-beta1(TGF-ß1) level. This study comprised 60 individuals diagnosed in newly onset T1DM. and 40 healthy contributors (control group). The patient group was divided into two subgroups according to age group G1(1-5) years and GII (6-10 years). The present study showed a significant increase (P = 0.05) of FBS and glycohemoglobin (HbA1C) levels in patients with GI compared with the GII. So this study explained a significant increase (P = 0.05) of FBS and (HbA1C) levels in patients with GI and GII compared with the control group. The present study showed a significant decrease (P = 0.05) of irisin levels in patients with GI compared with the GII. So this study explained a significant decrease (P = 0.05) of irisin level in patients with GI compared with the control group. While the results showed a significant increase P = 0.05) of irisin level in patients with GII compared with the control group. The present study showed a significant decrease (P = 0.05) of TGF-ß1 level in patients with GI compared with the GII. So this study explained a significant decrease (P = 0.05) of TGF-ß1 level in patients with GI and GII compared with the control group. The present study showed a significant increase (P = 0.05) of CRP level in patients with GI and GII compared with the control group. While the results explained a significant increase (P = 0.05) of CRP level in patients with GI compared with the GII.
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| Keyword:
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Irisin, T1DM, TGFß1.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.349
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| Download:
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