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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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The effects of irisin on the transforming growth factor-beta1(TGF-ß1) level in type-1 diabetic patients in Thi-Qar province.

Author: SAAD H.AL-BADRY, ALI A. AL-KHUZAIY, SHAYMAA A. KHALAF, ALI B. ROOMI
Abstract: The present study aimed at an assessment of irisin level in patients with the newly onset type 1diabetes mellitus" (T1DM) and their effects on the transforming growth factor-beta1(TGF-ß1) level. This study comprised 60 individuals diagnosed in newly onset T1DM. and 40 healthy contributors (control group). The patient group was divided into two subgroups according to age group G1(1-5) years and GII (6-10 years). The present study showed a significant increase (P = 0.05) of FBS and glycohemoglobin (HbA1C) levels in patients with GI compared with the GII. So this study explained a significant increase (P = 0.05) of FBS and (HbA1C) levels in patients with GI and GII compared with the control group. The present study showed a significant decrease (P = 0.05) of irisin levels in patients with GI compared with the GII. So this study explained a significant decrease (P = 0.05) of irisin level in patients with GI compared with the control group. While the results showed a significant increase P = 0.05) of irisin level in patients with GII compared with the control group. The present study showed a significant decrease (P = 0.05) of TGF-ß1 level in patients with GI compared with the GII. So this study explained a significant decrease (P = 0.05) of TGF-ß1 level in patients with GI and GII compared with the control group. The present study showed a significant increase (P = 0.05) of CRP level in patients with GI and GII compared with the control group. While the results explained a significant increase (P = 0.05) of CRP level in patients with GI compared with the GII.
Keyword: Irisin, T1DM, TGFß1.
DOI: https://doi.org/10.31838/ijpr/2020.12.04.349
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