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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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The response of hypoalbuminemia, hypocalcemia and hypercholesterolemia to regular treatment in a group of pediatric patients with nephrotic syndrome

Author: RAID HASHIM, ISRAA NATHIR, NADIA MOHAMMED KHALIL
Abstract: Background: Nephrotic syndrome represents a relatively common renal disorder in pediatric age group. It is commonly presented with a triad of edema, proteinuria and hypoalbuminemia. It has many histopathological types, with the minimal change disease being the most common type in children. This study aimed to evaluate the serum level of albumin, ionized calcium and cholesterol in patients already on treatment. methods: 58 pediatric patients with nephrotic syndrome have been enrolled in the current study. All participants were investigated for serum albumin, ionized calcium and cholesterol, in addition to the basic laboratory tests. The results were statistically compared to the reference range using GraphPad prism software. Statistical correlation between the studied parameters has been evaluated as well. Results: Mean serum albumin was significantly low (22.4 g/L ± 9.4), with 89% of participants had hypoalbuminemia. Mean serum cholesterol was significantly high (8.4 mmol/L ± 2.99), with 87% of participants had hypercholesterolemia, which has shown a strong negative correlation with serum albumin. Ionized calcium was normal in 97% of participants, where its mean was 1.13 mmol/L ± 0.2. Conclusion: Correction of hypoalbuminemia and hypercholesterolemia seems to be much more difficult in pediatric patients with nephrotic syndrome compared to hypocalcemia.
Keyword: nephrotic syndrome, hypercholesterolemia, hypocalcemia, hypoalbuminemia, pediatric
DOI: https://doi.org/10.31838/ijpr/2020.12.04.347
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