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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Expression Of (CD105) And ( VEGF-R3) In Dermoidcyst

Author: MUAZEZ ABDIL KHALIQ MALEH, IHSAN ABDULLAH KUMAIL
Abstract: Background :A dermoid cyst is a type of cystic teratoma which is benign in most cases, but in rare cases, it is malignant, a squamous cell carcinoma may developed in adults, and an endodermal sinus tumor in infants and children. Recurrence have been reported. Only limited studies have adopted stromal factors such as the role of angiogenesis and lymphangiogenesis. Aim of this study: to evaluate the mean density of vessels in dermoid cysts and investigate its possible relationship with biological behavior of these lesions. Materials and methods: Thirty formalin fixed paraffin embedded tissue blocks dermoid cysts which were collected from laboratory archive of histopathological laboratory of Al Hussain teaching Hospital included in this study .The samples were immunohistochemically stained with monoclonal antibodies against CD105 and VEGF-R3. Results: The mean of blood vessel density measured in all cases by CD105 immunomarker was (7.5833±2.55317). The mean of lymphatic vessel density measured in all cases by VEGF-R3 immunomarker was (4.6900±2.80152).However no significant relationship was found between CD105 expression dermoid cysts and presence or absence of daughter cyst (p=0.159), while high significant relationship was found between CD105 expression and inflamed dermoid cysts (p=0.0000). For VEGF-R3 expression statistically no significant relationship was found between dermoid cysts and presence or absence of daughter cyst (p=0.234) and presence or absence of inflammation (p=0.726). Conclusion: the study shows that angiogenesis might be one of the mechanism that is more possible to contribute the aggressive biological behaviors in dermoid cysts.
Keyword: dermoid cysts, CD105 immunomarker, VEGF-R3 immunomarker.
DOI: https://doi.org/10.31838/ijpr/2020.12.04.345
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