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Effects of statins on platelet count in hyperlipidemic patients
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| Author:
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HANI M.ALMUKHTAR, IBRAHIM M. FAISAL, MARWAN M. MERKHAN
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| Abstract:
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Statins are the strongest available lipid-lowering therapy and prescribed in nearly all patients with cardiovascular diseases. It play a great role in reducing morbidity and mortality associated with stroke diseases. Recently, it has been confirmed that the beneficial effects is far more than lipid-lowering actions; and pleiotropic effects have a complimentary role in cardiac diseases. Thrombocytopenia and platelet dysregulation could participate in reducing the cardiac disease fatality. This study aimed to investigate statin action on platelet following short-term use of lipophilic statin (atorvastatin) and hydrophilic one (rosuvastatin). Blood samples were collected from newly diagnosed patients and platelet counts are manually performed. Patients were assigned randomly into either atorvastatin or rosuvastatin use and blood sample collected before and after 6 weeks following therapy. The results revealed that platelet counts, bleeding or clotting time were non-significantly changed in both treated groups. The study concluded that neither lipophilic statin, nor hydrophilic ones, induced any changes with measured parameters; however, the limitation of our study include small sample size and lack of measuring of secretome parameters (fibrinogen, serotonin, and Ristocetin)
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| Keyword:
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bleeding, clotting , atorvastatin, rosuvastatin, statins, platelet.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.02.357
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| Download:
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Request For Article
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