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Some biochemical parameters and genetic aspect of ventricular septum defect patients in Thi-Qar province, Iraq
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| Author:
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KHALID G. AL-FARTOSI, ZAHRAA F. HASSAN, SHAYMAA JAWAD ABDULRAHMAN, ALI B. ROOMI
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| Abstract:
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The present study aimed to investigate some of the biochemical and genetic aspects of patients with a ventricular septal defect in Thi-Qar province, Iraq. The sample includes 75 patients who were attending Al- Nasiryiah heart center, during the period from December 2017 to March 2018, with 41 healthy as a control group. The result indicated a significant increase (at P=0.05) of TG,HDL and VLDL in VSD patients compared with the control group. while non-significant differences in Cholesterol and LDL in VSD patients compared with the control group. The results showed a significant increase (P= 0.05) of ALT, AST, ALP (at P= 0.05) in VSD patients compared with control. This study was conducted to identify the potential association of GATA4 gene SNPs with the progression of the ventricular septal defect (VSD) in Thi-Qar province in Iraq. One genetic locus covering 478 bp within the intronic region of the GATA4 gene was amplified and sequenced from both termini. Out of 20 sequenced samples in this locus, only one SNP was observed, namely rs10503425,which was found to be known with its association with VSD. The online available records of this SNP has indicated its pathological correlation with the progression of this congenital disease. The current results indicated that the distribution of the observed rs10503425 was only found in 6 examined samples, including samples no. 7, 10, 13, 14, 17, and 19. In conclusion, this observation may unmask more confirmation about the particular involvement of this discovered SNP in the progression of VSD in Thi-Qar population.
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| Keyword:
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Ventricular septal defect, Genetic aspect, Biochemical parameters.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.02.348
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| Download:
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