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The Relationships Between Acetylcholinesterase Activity and Some Ions (Calcium, Sodium) In Patients Diabetic Mellitus with Neuropathy in Babylon Province
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| Author:
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FIRDEWS Y.HAMZA, ODA M. YASSER
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| Abstract:
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The study was designed to understand the relationship between calcium ion, Enzyme AChE activity and Sodium ion in patients type 2 diabetes mellitus with neuropathy. A total of (167) Pearson ( 90 male , 77 female) ,from ( 113) patients suffering from type 2 diabetes mellitus (61 male, and 52 female) aged between 50 to 60 years . All have a history of disease of more than one year. The samples were obtained from Al-Marjan hospital in Hilla city, Iraq. The diabetic patients were diagnosed on the basis of WHO criteria. The study included three groups:
Group one: 68patients (39 males, 29 females) with type 2 diabetes mellitus with Neuropathy .
Group two: 45 patients (22males, 23 females) with type 2 diabetes mellitus .
Group three: 54 (29 males, and 25 females) apparently healthy subjects were chosen as healthy controls, they were non- smoker, alcohols, and did not have any history of chronic diseases.
In this study a statistically significant decrease is found in the activity of AChE (mU/ml) in type 2 diabetic patients with neuropathy as compared with other groups (type 2 diabetic patients without neuropathy and healthy ). The mean of acetylcholine esterase activity are 1444.53±136.69 in control group ,1466.22±157.77 in type 2 diabetic patients without neuropathy and 911.45±118.49 type 2 diabetic patients with neuropathy . There is highly significant p-value = 0.001. The mean serum Ca ion concentration (mmol/l) according to study groups (control ,DM without neuropathy and DM with neuropathy) are 2.17 ± 0.14,2.18± 0.18 and 2.24 ± 0.19 respectively.
The mean serum Na ion concentration is nearly the same in diabetic patients(with and without neuropathy),the mean was 141.59±5.41 and 141.69 ±5.05 respectively, while in control group was 144.12±5.52. The correlation between acetylcholine esterase activity (mU/ml) and Ca ion concentration (mmol/l) , and the correlation between acetylcholine esterase activity and Na ion concentration (mEq/l) in diabetic patients with neuropathy there are no significant correlation, p value = 0.408, r =0.115 , p value = 0.248, r =0.16 respectively. The correlation between Na ion concentration (mEq/l) and Ca ion concentration (mmol/l) in diabetic patients with neuropathy, there is non-significant correlation ,p value = 0.158, r =0.195.
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| Keyword:
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Calcium, Sodium, Neuropathy
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.01.337
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| Download:
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