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The Role of Interleukin-33 in Chronic Viral Hepatitis B Patients
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| Author:
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AQBAL SUHAIL NAJM ALJIZANI, ALIA ESSAM MAHMOOD ALUBADI, SAFAA ABDUL-KARIM ABDUL-RAZAK, ABBAS MAHMOOD AHMED
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| Abstract:
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Objectives
The aim of the current study was to determine the serum level of cytokine IL33 in patients with chronic HBV infection in comparison with the levels of this cytokine in healthy controls, assess the correlation between the levels of the cytokine IL-33 and liver enzymes which include ALT, AST, ALP, TSB levels and the viral load in the patients group.
Background
Hepatitis B virus (HBV) infection often leads to chronic infection, and cytokines have essential roles in viral infections. The interleukin 33 (IL-33) is a member of the IL-1 family, and have a pleiotropic function which influent in both innate and adaptive immune responses, many studies confirmed that the IL-33 involved in response to viral infections.
Materials and methods
The untreated chronic hepatitis B patients collected from Baghdad-medical-city, Hepatolog and Gastroenterology Teaching Hospital,
The level of IL -33, viral load, and level of liver enzymes were measured.
Results
IL-33 significantly increased in the chronic hepatitis B patients group than the healthy control group (P<0.0), this study did not observe any correlation between serum IL-33 level with ALP, AST, ALT, TSB and with viral load. The biochemical test results, ALT, AST, and TSB levels showed non-significant differences between the patients' group and the control group, while alkaline phosphatase (AP) has highly significant differences between the control group and the total of patients.
Conclusion
Our data indicated that serum level of IL-33 elevated with the in patients with chronic hepatitis B in comparison with healthy and there was no significant correlation between this interleukin (IL-33) with liver enzymes, and finally, there was no relation between viral load and IL-33 concentration.
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| Keyword:
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Hepatitis B virus, Interleukin-33, Viral load, Liver enzymes.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.01.334
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| Download:
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