|
Organs Protective Evaluation of Achillea Mellifolium Against Methotrexate Damaged Albino Male Mice
|
|
| Author:
|
ZEINA F.H.AL-OBAIDI, HAIDER N.YAHYA, ALI K.WANNAS, SABREEN ALI HADI
|
| Abstract:
|
The objective of this study was to consider as an explorer for in vivo studies on the named Achillea mellifolium. The present research was aimed to study the in vivo organ protective activity of ethanolic extract of Achillea melifoliumin by production of some secondary metabolites in methotrexate induced mice. A number of pharmacological and biological activities including antidiabetic, antidiarrhoeal, cytoprotective, antimutagenic, antioxidant, antimalarial, Antiinflammatory activities have been reported for this plant. The phytochemical investigation of Achillea melifoliumin have revealed the presence of polyphenol, flavonol glycoside, alkaloid, saponins, sesquiterpenoids and essential oil. Different organs were used in this study such as testes spleen, liver, kidney for this experiment. Each organ response was recorded and Histopathological section decleared the ability of plant extract to counteract the organs damaged by methotrexate (MTX) drug. .These results clearly well-known the protective potency organ of Achillea melifoliumin, which may explanation for some of the medical claims ascribed to this plant.
|
| Keyword:
|
Achillea millefolium, testes ,liver, spleen, kidney ,medicinal plant.
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2020.12.03.416
|
| Download:
|
Request For Article
|
|
|