|
Physiological Study For The Effects Of Tramadol On The Kidneys And Liver In Male Laboratory Mice
|
|
| Author:
|
YAQEEN AL-HUSSEINI, ALI B.ROOMI , MOHAMMED NAZAAL
|
| Abstract:
|
The current study was conducted to find out the physiological effects of tramadol on the kidneys and liver in male laboratory rats. The study period was from the beginning of November 2019 to the end of February 2020. 70 laboratory rats were used between the ages of 10-11 months and their weights ranged between 200-300 grams and distributed laboratory animals were randomly assigned to 6 groups each group of 10 laboratory animals where tramadol was injected at a dose of 8 mg/kg of body weight for 10, 20, 30, 40, 50 days, respectively, and the sixth group of tramadol was given for 30 days and then left for 10 days for hospitalization, and a group of laboratory animals was used as a control group for histological examination. Where the study showed that the examination of kidney tissue rats that were given tramadol for 10 days is a natural response to the reaction of Periodic acid–Schiff (PAS). While rats treated for 30 to 50 days with tramadol, there was a significant decrease in the pigment-responsive substances in the glomeruli of the kidneys and renal tubes, compared with the animals of the control group. Whereas, liver cells of rats that were given tramadol for 30 to 50 days showed a sharp decrease in protein content compared to liver cells of the control group. The glycogen content in the liver of rats treated with tramadol for 10 days was similar with the control group, whereas the group treated with tramadol for 30 days showed moderate glycogen depletion and this involved many hepatocytes, while treated rats for 50 showed a further depletion of glycogen compared with the control group liver cells.
|
| Keyword:
|
examination, tramadol, tissue, liver, kidney
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2020.12.03.414
|
| Download:
|
Request For Article
|
|
|