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Study of Central Venous Catheter-Related Infectionsin a Tertiary Care Teaching Hospital in India
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| Author:
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, RAJMANE T SHIVKUMAR, MOHITE S T
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| Abstract:
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Background and Aim: Central venous catheters (CVCs),though indispensable tools of modern clinical practice, lead to infections ranging from catheter site infection to colonization and bacteremia. Higher rates of CVC-related infections in India and conflicting results in established literature pertaining to the determinants of CVC-related infectionsinspired us to evaluate the infections related to CVCs and their antibiotic susceptibility pattern in ICU patients.
Methods: In this prospective study, a total of 68 ICU patients of either gender, with indwelling CVCs were included. Microbial surveillance was conducted byusing semiquantitative culture (SQC) method along with simultaneous blood cultures (BC) followed by antibiotic susceptibility tests. R version 3.6.0software was employed to analyze the data.
Results: Out of 68 samples,29 (42.6%) catheter tips werepositive on SQC (82.7% and 17.3% had definite CVC-associated infection and bacteremia, respectively) and 5 (7.3%) were positive onperipheral venous blood culture.Staphylococcus epidermidis (14; 20.6%) and S. aureus (7; 10.3%) were the most common pathogens identified.All staphylococcusspeciesshowedresistance to penicillin (100%) and ampicillin (100%), andsusceptibility to vancomycin (100%). Gram-negative bacilli showed maximum susceptibility to amikacin (6/34; 17.6%) while multidrug resistance (MDR)was observed in 22/34 isolates (64.7%). Catheterization duration of >3 days (24/29; 82.7%), non-elective procedures (20/29; 69%), and inexperienced venipuncturists (19/29; 65.5%)were found to be significant risk factorsofCVC-related infections (P<0.05).
Conclusion: In experienced venipuncturists, non-elective procedures, and prolonged catheterization were the significant risk factors of CVC-related infections, which were mostly caused by staphylococcusspecies. Thegram-negative bacilli causing theCVC-related infections were noted to be multidrug resistant.
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| Keyword:
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Nosocomial infections, multidrug resistance, staphylococcus aureus
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.03.411
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| Download:
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