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Evaluation of Association Between Glycemic Control and Lipid Profile in Type 2 Diabetes Mellitus
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| Author:
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, ANIKET BHASKAR AVHAD, SANJAY T.THORAT
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| Abstract:
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Background: Type 2 diabetes mellitus (T2DM) is among the most common secondary causes of dyslipidemia. Diabetic dyslipidemia is known to be a major risk factor for coronary heart disease. Therefore, critical evaluation of serum lipid profile in T2DM continues to be important.
Objective: To evaluate the relationship between glycemic control and serum lipid profile in patients with T2DM.
Methods: 100 adult type 2 diabetics attending a tertiary care hospital were recruited into the study. After detailed history and thorough clinical examination, laboratory investigations for evaluating glycemic status, including fasting blood sugar (FBS), post-prandial blood sugar (PPBS), glycosylated hemoglobin (HbA1c), as well as lipid profile, including total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and very low density lipoprotein (VLDL) levels in serum, were performed for all participants. The results were compiled, statistically analyzed and correlated.
Results: The glycemic status (mean HbA1c levels) showed a significant positive correlation with the mean serum levels of TC (p=0.035) and TG (0.016), but a negative correlation with the mean serum levels of HDL (p=0.09). TC levels >200mg/dL and TG levels >135mg/dL were seen more in patients with poor sugar control (HbA1c >6.5) as compared with the patients with good sugar control (HbA1c <6.5) (p<0.05). There was no significant correlation found between glycemic levels and age, FBS, PPBS, LDL and VLDL (p>0.05).
Conclusion: Good glycemic control is associated with a significant improvement in lipid profile.
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| Keyword:
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Type 2 diabetes mellitus, Dylipidemias, Glycated Hemoglobin A
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.03.409
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| Download:
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