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Comparative Study of the Diagnosis of Cervical Lymphadenopathy with Fine Needle Aspiration Cytology and Histopathology
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| Author:
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, NEHA SURESHKUMAR SHARMA, SUJATA R.KANETKAR, GARIMA AGARWAL, NITESH NASRE, SHOAIB KHOJA
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| Abstract:
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Background
Cervical lymphadenopathy is a very common clinical manifestation of many diseases.Excisional biopsy followed by histopathological examination is the optimum protocol for the diagnosis of cervical lymphadenopathy. However, it cannot be used in initial pathological examination as it is a surgical procedure involving potential complications.
Objective
To assess the accuracy of FNAC in the diagnosis of cervical lymphadenopathy and compare it with histopathology.
Materials and Methods
In this prospective study, 167 patients with cervical lymphadenopathy who underwent either FNAC or biopsy were selected. Of these, 126 underwent FNAC only, 26 underwent FNAC and biopsy, and 15 underwent only biopsy. FNAC was carried out, smears prepared on slides and stained with hematoxylin and eosin (H&E), Giemsa, or Ziehl-Neelsen stain. Excisional biopsy was followed by grossing and sectioning according to Rosai,10 and H & E staining. The sensitivity and specificity of FNAC were calculated, andthe correlation and degree of agreement between the FNAC and biopsy findings were determined using Cohen’s kappa coefficient (?).
Result
The maximum number of cases wasin patients who were in the 3rd decade (19.77%) of life followed by those in the 5th and 7th decade. The mean age of presentation was 40.67 years. There was a slight male predominance with maletofemale ratio being 1.1:1 (males: 88 (52.69%); females: 79 (47.31%).FNAC demonstrated a sensitivity of 94.44%, a specificity of 100%, a positive predictive value of 100%, a negative predictive value of 88.89%, and an accuracy of 96.15% compared to biopsy findings. There was an almost total correlation between FNAC and histopathology.
Conclusion
CL is the presenting sign in a heterogeneous group of diseases with variations according to age, geographical distribution, anatomical location of the CL, and the signs and symptoms; a thorough knowledge of which allows for rapid diagnosis and treatment planning.
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| Keyword:
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Biopsy Fine-needle, Histopathology, Lymphadenopathy, Lymph nodes, Neck
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.03.407
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| Download:
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