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Comparative Study of Misoprostol and Dinoprostone Gel for Cervical Ripening and Induction of Labor
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| Author:
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PALLAVI PANT, R. P. PATANGE, SANJAY PATIL
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| Abstract:
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Background: Although Dinoprostonehas long been used for cervical ripening due it is safety and efficacy profile, itis expensive.Recent reportshave suggested that Misoprostol might be more effective but less safe at higher doses than Dinoprostone in pregnant women.
Objective: To compare the efficacy and safety profile of low-dose Misoprostol with Dinoprostone for induction of labor in term pregnancies with unfavorable cervix and intact membrane.
Methods: Ninety-twosinglet on pregnant women of gestational age >37 weekswithno uterine contractions were divided into two groups with 46 subjects in each group.One groupreceived Misoprostol (25µg) vaginally andthe other groupreceived Dinoprostone(0.5mg) intracervical every 6 hours. Outcome measures such as Bishop score, mode of delivery, treatment cost, maternal complications, and neonatal outcomes were analyzed. Chi-square test, student’s t-test, and proportion test were used to compare Misoprostol with Dinoprostone.
Results: Themost common indication for induction was post-term pregnancy in both Misoprostol (69.57%) and Dinoprostone (39.13%) groups. The median dose in Misoprostol group was 3 doses (11.25 INR) and Dinoprostone was 1 dose (213.80 INR) (P<0.001). Most women in both groups achieved a Bishop score of >6 after induction (76.08% vs 80.43%).No maternal complicationswere recorded with Misoprostol (100%), whereas Dinoprostone had fever (2.17%), tachysystole (2.17%),and other complications (2.17%). NICU admission was required mostly in the Dinoprostone (6.52%)group compared to Misoprostol (4.35%).
Conclusion: Low-dose Misoprostol was as effective as Dinoprostone in the induction of labor and cervical ripening in term pregnancies.
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| Keyword:
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Uterine Contractions, Fetal Heart Rate, Off-Label Use, Cervix Uteri, Gestational Age
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.03.406
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| Download:
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