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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Prevalence of retinopathy of prematurity in less than 34 weeks preterm and their follow up: An observational study

Author: DR.VARSHA MANOHAR, DR.V.Y.KSHIRSAGAR, DR.DANESH B.POTDAR
Abstract: Background and objectives: Retinopathy of prematurity (ROP) is one of the major eye diseases prevalent in premature babies with an underdeveloped/ premature blood vessel in retina. The adequate screening, reporting and inadequate awareness about the dangerous consequences of this disease in neonates needs to be diagnosed, which otherwise may lead to blindness. The objective of this study was to evaluate the prevalence of ROP in <34 weeks preterm and to assess the risk factors causing ROP. Methodology: A descriptive observational study was performed in 140 neonates of <34 weeks gestational age and/or <1700 g birth weight. The neonates were assessed for the risk factors involved (gender, gestational age, birth weight, oxygen supply, ventilation support, surfactant, blood transfusion, anaemia, hyperbilirubinemia, and apnoea). Data was analysed using Cramer’s V test and regression analysis for assessment of risk factors in development of ROP. Results: Out of the total 140 babies, 27 showed ROP with the prevalence rate of 19.3%. With respect to risk factor assessment it was multifactorial, however, apnoea (P<0.001), ventilation (P=0.007), and gestational age (P=0.036) were highly significant. Apnoea had significant association (P=0.0194) as a risk factor and the odds of developing stage 2 ROP was 45.96 times more. Conclusion: Prevalence rate of ROP was 19.2% in the study population, with apnoea, gestational age and duration of ventilation being highly significant risk factors. Therefore, early identification of these risk factors may prevent the occurrence of ROP.
Keyword: Apnoea, Birth weight, Blindness, Gestational age, Hyperoxia
DOI: https://doi.org/10.31838/ijpr/2020.12.03.402
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