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Characteristics of Elevated Troponin-I In Acute Ischemic Stroke
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| Author:
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, GAURAV DWARKADAS JAJU, SHILPA PATIL, MAKRAND MANE, VIRENDRA C.PATIL
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| Abstract:
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Background: Cardiac troponins are highly sensitive and specific to myocardial damage, and elevated troponin I (cTnI) levels are frequently found in acute ischemic stroke (AIS) patients. However, the clinical significance of elevated troponin I in AIS is still undetermined.
Objective: To evaluate the relation between cTnI levels and acute ischemic stroke in patients without coronary artery disease (CAD) and assess the outcomes.
Methods: A total of 100 AIS patients of both sexes, aged above 18 years, and without CAD were included. Data on the demographics and comorbidities were collected, and laboratory investigations including lipid profile test, serum creatinine, hemoglobin (Hb), and cTnI were performed and recorded. Statistical analyses such as Chi-square test, Mann-Whitney U test, and Pearson’s correlation were performed by using R software version 3.6.0.
Results: A significant association was seen between elevated cTnI and mortality (P<0.001). Furthermore, the mean age (68.27±13.25 years) was higher, and Hb was significantly lower in patients with elevated cTnI (P=0.008). History of tobacco use was found in 15% of the patients with elevated cTnI. No significant association was observed between elevated cTnI and gender, chest pain, tobacco use, alcohol consumption, and presence of comorbidities (diabetes, hypertension, and dyslipidemia [P>0.05]). A significant correlation was observed between serum creatinine and elevated cTnI (P<0.05).
Conclusion: Elevated cTnI in acute ischemic stroke patients was associated with a significant mortality rate.
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| Keyword:
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Troponin I, Coronary Artery Disease, Stroke, Biomarkers, Mortality
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.03.397
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| Download:
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Request For Article
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