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Oral Pregabalin Versus Oral Pregabalin Plus Intravenous Fentanyl: In Search of a Better Attenuator for Pressor Response to Laryngoscopy and Tracheal Intubation
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| Author:
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ANUSHA R.KATTI, NASEEMA V. KANASE, VISHNU MADHUSOODANAN NAIR, V. K DULKHED, GAURI KANGRALKAR
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| Abstract:
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Background and Aim: In recent times, nonopioid analgesics such as gabapentin and pregabalin are being used in preoperative setting for anxiolysis and attenuation of pressor response to endotracheal intubation and laryngoscopy but with conflicting results. Hence, we intended to evaluate and compare the efficacy of pregabalin as premedication alone and in combination with intravenous fentanyl in elective surgeries.
Methods: A total of 60 patients aged 18-50 years, with ASA status I and II, and scheduled for laparoscopic surgeries were randomly allocated to Group P (n=30) and Group PF (n=30) by sealed envelope comprising coded study drugs. Group P received oral pregabalin 150 mg an hour before induction of general anesthesia, whereas Group PF received oral pregabalin 150 mg and intravenous fentanyl 2 µg/kg five minutes before induction. Hemodynamic parameters, analgesia (by Visual Analogue Scale), and sedation scores (by Ramsey Sedation scale) were compared between the two groups. Software R version 3.6.0. was employed to analyze the data.
Results: The mean heart rate, systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure were significantly higher in Group P immediately after laryngoscopy and intubation and 1 min after intubation (P<0.0001). No significant difference was observed between the two groups with respect to requirement of intraoperative and postoperative analgesia (P=0.061 and P=0.56, respectively). None of the patients in either group experienced postoperative nausea, vomiting, or intraoperative shivering.
Conclusions: Combination of pregabalin and intravenous fentanyl was more effective in attenuating pressor response to laryngoscopy and endotracheal intubation compared to pregabalin alone.
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| Keyword:
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Anxiolysis, analgesics, endotracheal intubation, laparoscopy
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.03.392
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| Download:
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