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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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An Evaluation of Antimicrobial Effect of Sodium Valproate Against Orodental Pathogens

Author: CHAITANYA P, EZHILARASAN D
Abstract: Introduction Sodium valproate is an anticonvulsant drug used in the treatment of epilepsy and also in treatment of neuropathic pain, bipolar disorder, epileptic seizures etc. In the present study we assessed the antimicrobial activity of sodium valproate against the following oral pathogens: E.faecalis, S.mutans, S.aureus, Pseudomonas sp., and C.albicans. Materials and methods Enterococcus faecalis, Streptococcus mutans and other oral pathogens were procured from this institute. Organisms were cultured using standard methodology. Minimum inhibitory concentration (MIC) and Minimum bactericidal concentration (MBC) was studied using agar well diffusion method. Results Sodium valproate inhibited the growth of all microorganisms tested. The maximum zone of inhibition was found against C.albicans when compared to other pathogens. Sodium valproate is highly effective against the tested pathogens especially against C.albicans. Conclusion Sodium valproate can be preferred as a drug of choice for oral thrush and other oral infections caused by the orodental pathogens after proper dose adjustments.
Keyword: anticonvulsant, antimicrobial, oral pathogens, sodium valproate, C.albicans
DOI: https://doi.org/10.31838/ijpr/2020.12.04.340
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