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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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High Mobility Group AT-Hook 2 expression is elevated in cervical cancer

Author: MONICA HARTANTI, ELSHA DWI ANGGUN RACHMADHANY, ITA TAZKIATUL IZZATI MUSTOPA, ELRIAN SYAPUTRA, ELFIRA SUTANTO, GATOT PURWOTO
Abstract: Cervical cancer is the fourth most common type of cancer in women after breast, colorectal, and lung cancers. Cervical cancer is a disease caused by the Human Papilloma Virus (HPV). A previous study found “hot spots” in the human genome that is predicted to be integration points of HPV containing several genes, such as high- mobility group AT-hook 2 (HMGA2), semaphorins Class3 Subgroup D (SEMA3D), and kruppel-like factor 12 (KLF12). Various studies have shown that these genes play a critical role in cell proliferation, apoptosis, migration, which are important factors in the development of cancer. This study explores the DNA expression of the HMGA2, SEMA3D, and KLF12 genes in cervical cancer. Using qPCR, this cross-sectional study analyzed those gene expressions quantitatively in normal and cervical cancer groups. An independent t-test was used to analyze the data and p<0.05 was considered significant. There was a significantly higher expression level of HMGA2 in the cervical cancer group compared to the normal group. Other genes were expressed lower in the cervical cancer group compared to normal although it was not statistically significant. HMGA2 might have an important role in the development of cervical cancer.
Keyword: cervical cancer, HPV, DNA, gene expression
DOI: https://doi.org/10.31838/ijpr/2020.12.04.322
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