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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Factors affecting the quality of life of Thallasemia ß major children

Author: MEIYANTI , NOVIA INDRIANI S, EVELINE MARGO, LIE T MERIJANTI S
Abstract: Thalassemia is a genetically inherited blood disorder. According to the World Health Organization, 40% of the cases of thalassemia are in Asia. The main treatment for this disease is through administration of blood transfusions and iron chelation therapy. Generally, this chronic condition has an impact on the quality of life of patients due to the course of the disease and its treatment. Therefore, the purpose of this study was to determine the factors affecting the quality of life of thalassemia patients. The cross sectional design method was used in this research. The research subjects were 73 ß major thalassemia children, aged 8-18 years, undergoing treatment at the Bogor PMI Hospital, between January and March 2020. These were selected through consecutive non random sampling technique. Variables measured include serum ferritin and haemoglobin levels, as well as blood transfusion compliance and consumption of iron chelation, through questionnaires, while the quality of life was measured through PedsQL generic 4.0. The data were subjected to Pearson and Spearman correlation tests. Based on the result, the mean age of the thalassemia major children was 13 ± 4 years, while the value of the quality of life was 67.10 ± 11.27. There was a positive significant relationship between parental education (r = 0.236, p = 0.045), parental income (r = 0.264, p = 0.024) and the average value of quality of life. Also, there was a negative significant relationship between the average quality of life value with the age of commencing blood transfusion (r = -0.255, p = 0.030). Furthermore, the higher the education level and income of the parents, the higher the quality of life of thalassemia children will be. However, the higher the age of administering blood transfusion, the lower the quality of life.
Keyword: Thalassemia ? Major, Child, Quality of Life
DOI: https://doi.org/10.31838/ijpr/2020.12.04.324
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