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New Dapsone Derivatives as potent Antibacterial Activity
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| Author:
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WALAA NAJEM, ALI FATTAH NASER, MANAL F. ALKHAQANI, FARKED WAHOODI SALMAN, ALI JABBAR RADHI
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| Abstract:
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In this work, new heterocyclic compounds 1,2,3-triazoline derivatives starting from dapsone were synthesized. At first dapsone was converted to 4,4'-sulfonylbis(azidobenzene). 1,2,3-triazolines were prepared from reaction 4,4'-sulfonylbis(azidobenzene) with some unsaturated compounds such as acryl amide, cenamic acid and malic anhydride by click reaction. The products were identified by 1HNMR, FTIR spectroscopy and element analysis. All target compounds were tested for antibacterial activity by using Gram-positive bacteria St. aureus and Gram negative bacteria E. coli. The antibacterial drug Azithromycin were used as control drug. All tested compounds were be found more active compound among the synthesized was d1 against E. coli but against St. aureus were compounds d1and d3.
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| Keyword:
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Dapsone, 1,2,3-triazolines, Antibacterial activity.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.03.359
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| Download:
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