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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Comparative biological studies, phytochemical screening and GC-MS analysis of some Egyptian Red Sea macroalgae

Author: SHIMAA AHMED, AZIZ A. RAHMAN, KHALED N. M. ELSAYED, SAYED A. AHMED
Abstract: Marine macroalgae are useful for human as a source of bioactive constituents and nutraceuticals. The objective of the present study was to evaluate the cytotoxic, antimicrobial activities and phytochemicals of brown macroalga (Hydroclathrus clathratus), green macroalga (Caulerpa serrulata) and red macroalga (Galaxura elongata) from the Red Sea. Cytotoxicity was assayed against HepG-2 and MCF-7 cell lines. The antimicrobial activity was examined against six pathogenic bacteria and three fungi by the well diffusion method. Hydroclathrus clathratus showed the strongest cytotoxic effect against HepG-2 and MCF-7 cell lines with IC50 value of (24.8? 1.1and 26.6?1.2 µg/ml) respectively. Maximum inhibitions were displayed by Galaxura elongata against candida albicans (16.07?0.21mm) and Hydroclathrus clathratus against Aspergillus fumigatus (15.20?0.26 mm). The extracts of the three algae species were further investigated by general standard tests and GC-MS analysis to identify the phytochemicals. Phytochemical screening revealed that the algae contain flavonoids, carbohydrates, terpenoids, saponins, steroids and phlorotannins. GC-MS analysis showed that methyl hexadecanoic acid, was the most abundant component (15.07%) in macroalgae.
Keyword: Macroalgae, Phytochemicals, Cytotoxicity, Antimicrobial, GC-MS.
DOI: https://doi.org/10.31838/ijpr/2020.12.04.009
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