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The Effect of Kebar Grass (Biophtyum petersianum Klotzsch) Extract on the Number of Leydig Cells of Mice (Mus Musculus) Treated with TCDD
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| Author:
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MILLA NURSADIDA, HANI PLUMERIASTUTI, YENI DHAMAYANTI, WIDJIATI, EPY MUHAMMAD LUQMAN
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| Abstract:
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This study aimed to examine the effect of kebar grass extract on the Leydig cells number of mice to exposed 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD). These animals were divided into five groups. Twenty five BALB/C mice were used with five groups: Negative Control (C-), Positive Control (C+) with TCDD 7µg/kgBW IP, and treatment groups that treated with TCDD 7µg/kgBW IP and Kebar Grass orally for 53 days were presented T1 0,045mg/gBW/day, T2 0,080mg/gBW/day, and T3 0,135mg/gBW/day. Results showed that TCDD decreased the Leydig cells number, while kebar grass extract was increase the number of Leydig cells exposed by TCCD significantly (p<0,05). But the increase in the number of Leydig cells had not yet reached the normal number of Leydig cells.
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| Keyword:
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Kebar Grass, Biophytumpetersianum Klotzsch, Leydig cells, TCDD, mice
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.315
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| Download:
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