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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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The Effect of Kebar Grass (Biophtyum petersianum Klotzsch) Extract on the Number of Leydig Cells of Mice (Mus Musculus) Treated with TCDD

Author: MILLA NURSADIDA, HANI PLUMERIASTUTI, YENI DHAMAYANTI, WIDJIATI, EPY MUHAMMAD LUQMAN
Abstract: This study aimed to examine the effect of kebar grass extract on the Leydig cells number of mice to exposed 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD). These animals were divided into five groups. Twenty five BALB/C mice were used with five groups: Negative Control (C-), Positive Control (C+) with TCDD 7µg/kgBW IP, and treatment groups that treated with TCDD 7µg/kgBW IP and Kebar Grass orally for 53 days were presented T1 0,045mg/gBW/day, T2 0,080mg/gBW/day, and T3 0,135mg/gBW/day. Results showed that TCDD decreased the Leydig cells number, while kebar grass extract was increase the number of Leydig cells exposed by TCCD significantly (p<0,05). But the increase in the number of Leydig cells had not yet reached the normal number of Leydig cells.
Keyword: Kebar Grass, Biophytumpetersianum Klotzsch, Leydig cells, TCDD, mice
DOI: https://doi.org/10.31838/ijpr/2020.12.04.315
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