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An in Silico Approach To Identify The Potential Protein Targets Of Luteolin In Common Dental Pathogens
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| Author:
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SHREYA KOTHARI, J.VIJAYASHREE PRIYADHARSINI, SMILINE GIRIJA A.S
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| Abstract:
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The study aims to demonstrate the antimicrobial activity of luteolin against common dental pathogens using an in silico approach. Luteolin is a flavonoid rich in antioxidant, anticancer, anti allergic, and antihypertensive properties. Dental caries is one of the most common infectious diseases in humans. Periodontal disease is an inflammatory disorder manifested in periodontium mainly caused by P.gingivalis. Luteolin contains antifungal, anti influenza, anti malarial properties. The software used were STITCH for interaction of Luteolin with the proteome of bacteria, VICMPred for identification of functional class of proteins, VirulentPred for identification of virulence properties of proteins, BepiPred v2.0 for identification of epitopes on the virulent protein, PSORTb v3.0 –for identification of the subcellular location of the virulent protein. This approach gave a result at the molecular level and with its subcellular location, epitope and finding the virulence factor, luteolin was proved to be useful as an antimicrobial agent to eradicate dental pathogens.
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| Keyword:
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Luteolin, P.gingivalis, STITCH,VirulentPred.VICMPred
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.03.335
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| Download:
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