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The Role of Acute Phase Reactants in Periodontitis
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| Author:
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NASHRA KAREEM
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| Abstract:
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Periodontitis is basically inflammation of the supporting tissues of teeth caused by microorganisms. The initial event in the pathogenesis of periodontitis is the accumulation of bacteria embedded in a biofilm along the tooth surface. The complex formed due to interaction of endotoxins and toll-like receptors in the subgingival plaque, activates the signal transduction pathway in both innate and adaptive immunity resulting in production of cytokines that co-ordinate the local and systemic inflammatory response. The pro-inflammatory cytokines originating at the diseased site activates the liver cells to produce acute phase reactants or proteins as a part of nonspecific response. Acute phase reactants are a group of proteins. The plasma concentration of acute phase proteins increase or decrease in response to inflammation. This phenomenon is known as the acute phase reaction or acute phase response, which occurs approximately 90 minutes after the onset of a systemic inflammatory reaction. Acute-phase proteins play an important role in the inhibition of extracellular proteases, wound healing, blood clotting, fibrinolysis, modulation of immune cell function, and the neutralisation and clearance of harmful substances from the circulation. Therefore this review article highlights the role and association of acute phase reactants in periodontitis.
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| Keyword:
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periodontitis, acute phase proteins, cytokines, immunity
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.02.327
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| Download:
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