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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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The Effect of Aerobic Exercises on Cognition, Physical Fitness, and Apolipoprotein E Plasma among Women with Mild Cognitive Impairment

Author: , LISNA ANISA FITRIANA, SUCI TUTY PUTRI, KUSNANDAR ANGGADIREDJA, RIA MARIA THERESA, I KETUT ADNYANA
Abstract: Aerobic exercise is believed to improve cognition and physical fitness, but its effect on Apolipoprotein E plasma levels in humans is quiet limited. The purpose of this study was to analyze the effect of aerobic exercises on cognition, physical fitness, and Apolipoprotein E plasma among women with mild cognitive impairment (MCI). This study used the quasy experiment with the pre and post-test method with control group. The participant of the study included 32 women aged 44-61 years with MCI. They were divided into two groups; aerobic exercises group (2x60 minutes/week, n = 16) and control group (n = 16). The intervention was carried out for 16 weeks. The inclusion criteria of this study is those who had MoCa-Ina test score = 26, had good vision and hearing, did not have severe illness, and did not exercise at least 3 months before the experimentation. The results showed that aerobic exercises can improve memory (p = 0.002), improve one-leg balance with open eyes (p <0.001), one-leg balance with closed eyes (p = 0.017), and lower extremity strength (p = 0.001), and reduce Apolipoprotein E plasma significantly (p =0.001) in women with mild cognitive impairment. In conclusion, aerobic exercises could have positive effect on memory, physical fitness, and Apolipoprotein E plasma levels in MCI women. Further studies can be conducted regarding to the effects of aerobic exercise in older adults w ith dementia.
Keyword: aerobic exercise, apolipoprotein E, cognition, mild cognitive impairment, physical fitness
DOI: https://doi.org/10.31838/ijpr/2020.12.01.268
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