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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Effect of new synthesized compounds of 2-Thiouracil Sulfonamide Derivatives against colon and liver carcinoma cells “In Vitro Study"

Author: SAIF M.HASSAN, ASHWAQ NAJEMALDEEN ABBAS AL-JAF, YASMEEN ALI HUSSIEN, SAMIR M.AWAD, MAYSAA ALI ABDULKHALEQ, NAJAH R.HADI
Abstract: Many studies have been focusedon 2-Thiouracil derivatives as an anti-cancer therapy. The target compounds were prepared to be tested on colon and liver carcinoma cells and compared them with 5-FU. The newly synthesized compounds were showed variable effectiveness against colon cancer; however, the most active compounds were carbothioamides7a and 7c which showed high activity against both types of cell lines. Moreover, the 4a-c, 5a-c, and 6a-c compounds were showed ineffectiveness against liver cancer while other compounds were showed cytotoxic activity more than 5-FU especially 7a, 7c, and 3a, we are recommended that need to study the toxicity effect of these effective compounds and tested them in vivo.
Keyword: synthesized compounds, Thiouracil Sulfonamide, colon, liver carcinoma cells
DOI: https://doi.org/10.31838/ijpr/2020.12.04.286
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