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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Serological and molecular detection of Epstein –Barr virus (EBV) in patients with malignant lymphoid solids

Author: SALWA S.SHIHAB, HAYDER ABDULHUSSEIN AL-HMUDI, SADEQ K.ALI.AL.SALAIT
Abstract: Background: Epstein-Barr virus (EBV) is a common herpesvirus can be associated with numerous infections and cancers. This study aimed to diagnosis of EBV among malignant lymphoid solids of patients in Basrah province/Iraq. Patients and Methods: A 120 blood samples of both sexes with the age range 6 months to 93 years’ old were collected from patients with malignant lymphoid solids. All serum samples were examined to detect EBV biomarkers including (anti-EBV-CA (IgG), anti-EBV-CA (IgM) and anti-EBV-NA-(IgG) antibodies. The nested PCR protocol was used to amplify two DNA fragment of EBV. Results: The results of patients showed positive sera of 14/120(11.66%), 120/120(100%) and 111/120(92.5%) of anti-EBV capsid antigen IgM, anti-EBV capsid antigen IgG and anti-EBV nuclear antigen IgG, respectively. The present study was showed 4 statuses (Table, 1) among studied groups; a 99/120 (82.50%), 12/120 (10.0%), 7/120(5.83%) and 2/120(1.66%) patients as seropositive infection, reactivated infection, old infection and recent primary, respectively. EBV-DNA was detected in 44/120(36.7%) and 35/100(35%) in patients and control groups, respectively. Conclusions: we concluded that highly seroprevalence of EBV among malignant lymphoid solids patients.
Keyword: Epstein-Barr virus, Acute lymphoblastic leukaemia, Hodgkin lymphoma.
DOI: https://doi.org/10.31838/ijpr/2020.12.02.306
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