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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Pathological and Enzymatic Effect of Corynebacterium Pseudotuberculosis in the Liver of Mice Infected by Same Pathogen

Author: K.J.AWNI , MUAYAD ABBAS HUSSEIN, T.G.Y.AL BADRRAWI, HUSSEIN H.NAHI
Abstract: A designed study was done to detect the pathological and enzymatic effect of Corynebacterium Pseudotuberculosis in the liver of mice infected with virulence strain of this C. pseudotuberculosis. Twenty mice were divided into two groups equally: G 1 were act as control negative administrated 0.3 ml of phosphate buffer saline (PBS) intraperitoneal, while G2 were infected (challenged) intraperitoneally with 0.3 ml of virulent C. pseudotuberculosis containing (5×109) CFU/ ml. During 30 and 60 days, post-infection five animal from each group were sacrificed and blood collecting to detected the serum enzymes for Alanine transaminase (ALT), Aspartate transaminase (AST), Alkaline phosphatase (ALP) and Gamma-glutamyl transpeptidase (GGT) were done, in addition to small pieces from liver were processed for histopathology. The results revealed that elevated levels of the liver enzyme in group 2 (G2) at thirty and sixty days compare with group1(G1), also sever pathological effect in the liver including injury, damage, caseous necrosis with presence of inflammatory cell especially neutrophils at thirty days post-infection and micro abscess with pyogranuloma with infiltration of inflammatory cells especially lymphocytes macrophages.
Keyword: C. pseudotuberculosis, Caseous Lymphadenitis, Liver and Mice.
DOI: https://doi.org/10.31838/ijpr/2020.12.04.273
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