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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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The Use of Pharmaceutical Preparation of Phytosome Lepidium Sativum Extract as Anti-diarrheal Induced by the Bacteria E. coli in Mice

Author: FARRAH R.JAAFAR, SHROOQ J.JASSIM, MOHANAD A.AL-BAYATI
Abstract: Lepidium sativum has a varied biological effect such as sedative, anti-inflammatory, antiemetic, and reduce pregnancy pains. Besides, it was helpful in asthma. Furthermore, act as astringent of GIT. Study the therapeutic effect of phytosome as anti-diarrheal induced by the bacteria E. coli in mice, (seven groups) Treated orally with (phytosome Lepidium sativum extract) extract at doses of 0, 50, 100,150, 200, 250, 200 mg/Kg B.W. The total number of mice (140) was distributed into fourteenth groups these groups were divided into equal same main functional working subgroups: half one of groups (seven groups) for in vitro tests and second (seven groups) for in vivo tests. Each subgroup was divided according to Lepidium sativum extracts doses treated animals. The result showed a significant decrease in diarrhoeal incidence and Percent of Charcoal-induced gut transit\ cm with increasing doses of Lepidium sativum extracts phytosome and syrup dosage form with a significant increase in expulsion time with increase doses. Conclusion: phytosome Lepidium sativum reduced diarrhea by inhibiting intestinal motility or it could help to release endogenous substances from conducted with neural or non-neural basic of peripheral origin derived an excitatory outcome at the pre-junctional site or it may exert the antispasmodic effect via stimulating intestinal smooth muscles directly.
Keyword: Phytosome Lepidium Sativum, Pharmaceutical Preparation, Anti-diarrheal.
DOI: https://doi.org/10.31838/ijpr/2020.12.04.269
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