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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Analyzing the deduction of Serum Levels with Coronary Heart Disease

Author: ALII MOHAMMED, REZANI MAJEEDI OMER, SAMIRI ANWARI JABBAR
Abstract: The main purpose of this article is to assess the association between subclinical hypothyroidism and/or autoimmune thyroid disease and coronary heart disease. Fifty-six patients identified as having coronary heart disease by a coronary angiography and eighty-seven healthy subjects matched for age, sex and body mass index are involved in this article. Serum lipid concentrations, thyroid function, and thyroid autoantibodies are evaluated in the coronary heart disease and control groups. The coronary heart disease group exhibited significantly decreased serum free T3 (FT3) and free T4 (FT4) levels, and significantly increased serum TSH levels as compared with the control group, indicating a significant decrease in thyroid function in the coronary heart disease patients. Serum high density lipoprotein cholesterol (HDL-C) levels were significantly decreased in the CHD group. The incidence of subclinical hypothyroidism and thyroid autoantibodies were similar in both two groups. Patients with coronary heart disease had significantly lower serum levels of HDL-C than the control subjects, regardless of gender (P<0.01). In the group with coronary heart disease, there was no difference between the serum lipid levels in patients with subclinical hypothyroidism and those with normal thyroid function. Female patients with CHD had significantly lower serum levels of thyroid hormone and HDL-C, but their subclinical hypothyroidism or thyroid autoimmunity did not seem to be related to the development of coronary heart disease
Keyword: Autoimmune thyroid disease Subclinical hypothyroidism, Coronary heart disease.
DOI: https://doi.org/10.31838/ijpr/2020.12.04.254
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