IJPR  articles are Indexed in SCOPUS (2010 - 2021)Click Here     *Five Years Citation in Google scholar (2016 - 2020) is. 1451*        Now IJPR is Q2 in SJR Ranking     Scopus Coverage of IJPR (2010-2021 Issue 1)          Journal is Currently Not Indexed in Scopus as on february 2021 list provided by scopus

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
No Data found.
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Comparative Diagnostic Value of Anti-Dengue IgG, Anti-Dengue IgM of Two Rapid Tests in Dengue Virus Infection

Author: MAY TANZILIA, NELLY ZUROIDAH, I GUSTI AGUNG AYU EKA PUTRI SUNARI, BILLY JORDAN WRAHATNALA, FARADILA KHOIRUN NISA, HAKIM, ALI ROHMAN, PUSPA WARDHANI, DOMINICUS HUSADA, SITI NADIA TARMIZI, ARYATI
Abstract: Introduction: Diagnosis of Dengue Virus Infection (DVI) is based on combination of clinical manifestation, hematological, serological, and molecular examination. This study aims to compare the diagnostic value of anti-dengue IgG and anti-dengue IgM by two rapid tests with RT-PCR Dengue and ELISA as the gold standards. Methods: This was an observational cross-sectional study. Serum was collected from 80 febrile patients (3-7 day fever), who were suspected Dengue Virus Infection (DVI). Serum was examined by STANDARD Q-SD and SD BIOLINE as rapid tests and RT-PCR and or NS1 Ag Dengue (ELISA) and anti-dengue IgG/IgM ELISA as the gold standards. Results: The most common serotype identification was DENV 3. The positive results of NS1 Ag Dengue were common on day 3 of fever in primary infection and day 4 of fever in secondary infection. The antibody examination was dominated by positive anti-dengue IgM and positive anti-dengue IgG in 27 patients (54%) in secondary infection. Sensitivity anti-dengue IgG STANDARD Q was 68%, and SD BIOLINE was 87%. Specificity anti-dengue IgG STANDARD Q was 80%, and SD BIOLINE was 76.7%. Sensitivity IgM anti-dengue STANDARD Q was 44%, and SD BIOLINE was 48%. Specificity anti-dengue IgM of two rapid tests was 100%. Conclusion: The serological examination with rapid tests is not enough to establish a diagnosis of DVI, so the combination with NS1 Ag Dengue and RT-PCR examination is needed.
Keyword: Dengue virus, diagnosis, rapid test, ELISA
DOI: https://doi.org/10.31838/ijpr/2020.12.04.241
Download: Request For Article
 




ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
SCImago Journal & Country Rank

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free