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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Assessment of Serum Zinc and Vitamin C as Antioxidants in Patients with Vitiligo in Babylon Province

Author: HADEER AL-HATTAB, BAN MAHMOOD SHAKER AL-JODA, MOHAMMED KADHUM AL-HATTAB
Abstract: Bachground: Vitiligo is a common depigmentation disease , characterized by the white (depigmented) spots of the skin. The vitiligo pathogenesis is still to be elucidated. The reduction of antioxidants in circulation might be the most important characteristic in vitiligo pathogenesis. Zinc (Zn) is an essential trace element and involved in gene transcription, lipid and protein function. Its role in human body includes, wound repair, immune function, reproduction, and on the microcellular level, macrophage, natural killer cell, complement activity. Zinc was found in many food types, like legumes, fish, meat, and other foods. Ascorbic acid is a hydro-soluble antioxidant sometimes called vitamin C. In physiological pH, vitamin C is primarily found as an ascorbate anion. Ascorbic acid has 4 -OH groups capable of giving hydrogen to the oxidizing system. The aims of this study are to measure the serum level of vitamin C and Zn as an antioxidant parameter in patients with vitiligo and healthy control and to assess the relation of each with that dermatological illness. Methodology: We measured the serum vit. C and Zn as antioxidants in 50 vitiligo patients and fifty healthy individuals as a control. The serum Zn levels were calculated using atomic absorption spectroscopy and levels of serum vitamin C were detected via enzyme linked immunosorbent assay (ELISA). The VASI score was also measured for each vitiligo patients. Results : After the comparisons and measurements of antioxidants in vitiligo patients and gender and age-matched "control group", the results showed a significantly lower vitamin C than the controls. Serum Zn levels were substantially lower in vitiligo patients, compared to the controls. Conclusion: The serum levels of vitamin-C and zinc as biomarkers of anti-oxidative stress, were decreased among vitiligo patients, compared with the control group. These findings further support the associations between oxidative stress and free radical-mediated destruction of melanocytes or dysregulation of melanogenesis in the pathogenesis of vitiligo.
Keyword: Vitiligo, Antioxidants, Zinc, Vitamin C.
DOI: https://doi.org/10.31838/ijpr/2020.12.04.237
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