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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Health Benefits of Green Tea and Green Tea Catechins with an Overview on their Anti-Cancer Activity

Author: AMEERA KHALEEL, DR. RAMIZU BIN SHAARI, DR. MOHAMAD ARIF AWANG NAWI, DR. ALI SULTAN ALRIFAI
Abstract: It was found that green tea (GT) and its catechins, can decrease the malignant behavior of several tumors and inhibit metastasis and lower the recurrence rate. The purpose of this paper was to review the literature about the different anticancer activity of GT with particular focusing on the molecular mechanisms and molecular targets underlying this activity. The mechanisms underlying the anti-cancer activity are the enhancement of apoptosis and inhibition of the proliferation of malignant cells, mutagenesis and genotoxicity inhibition, decrease the expression levels of VEGF, inhibition of NK-?B and AP-1 activity, inhibiting nitric oxide production, inhibition of TNF-a, COX-2, MMP2, MMP- 9 expression and receptor tyrosine kinases pathways, increase sensitivity of anticancer agents, antioxidant/induction of oxidative stress, immunomodulation against malignancy, and anti-metabolic syndrome effects. Understanding of all the detailed pathological roles of green tea against tumors is important to evaluate the preventive measures and the treatment of different types of malignancy
Keyword: Green tea, Green tea polyphenols, Cancer, Catechins, Apoptosis.
DOI: https://doi.org/10.31838/ijpr/2020.12.04.233
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