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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Effect of Methanol Watery Extract of Cuscuta Chinensis in Rheumatoid Arthritis Induced Rats.

Author: AHMED SAADOON, DR.MUSTAFA GHAZI ALABBASSI , DR.NADIA HAMEED MOHAMMED
Abstract: Background Rheumatoid arthritis (RA) is a chronic destructive inflammatory disease related to a breakdown in immune tolerance. This disease is characterized by joint inflammation, swelling, and in severe cases deformation may occur. Cuscuta Chinensis (C. Chinensis) is a parasitic plant, grow around other plants to absorb nutrient and water from them. C. Chinensis has a wide range of chemicals that produce a wide range of pharmacological activates. Because of its anti-oxidant and anti-inflammatory effect, it was considered as a good candidate to assess its role in RA. Methods: Rheumatoid arthritis was induced by injection of Complete Freund’s Adjuvant inside the foot-pad of male albino rats. The animals were grouped in four groups as follows group 1 considered as a normal control group, group 2 consider as positive control arthritis, group 3 treated with 500 mg/kg C. Chinensis crude extract, group 4 treated with Methotrexate (MTX) as stander treatment. On day 14 of immunization, treatments began and last for 21 days, at the end of the experiment all animals were sacrificed and serum was collected. The serum markers that had been evaluated were MMP3, VEGF, and SOD in addition to PGE2 which was evaluated by Immuno-histochemical (IHC) stain. Throughout the experiment time the arthritis index was evaluated. Results C. Chinensis extract significantly (P value = 0.05) improves objective parameter of RA which was the arthritis index. Also significantly decrease (P value = 0.05) the serum level of MMP3, VEGF, and considerably increase serum SOD. IHC showed that C. Chinensis reduce the ratio of positively stained cells. Conclusion: The extract has a significant beneficial role in suppression of destructive enzyme (MMP3), angiogenic stimulators (VEGF), and increase serum SOD enzyme.
Keyword: VEGF, SOD
DOI: https://doi.org/10.31838/ijpr/2020.12.04.229
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