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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Relationship between Mean Platelet Volume and Platelet Distribution Width with Type of Diabetic Retinopathy

Author: LIBRIANSYAH , SOEBAGIJO ADI SOELISTIJO, AGUNG PRANOTO, WIMBO SASONO, DEASY ARDIANY
Abstract: Introduction: Platelet activity is increased in people with diabetes mellitus (DM). This increase indicates vascular impairment or increased inflammation. Mean Platelet Volume (MPV) and Platelet Distribution Width (PDW) are specific parameters of those activity. Diabetic Retinopathy (DR) is one of the many microvascular complications suffered by DM patients. The aim of this study was to analyze the relationship between MPV and PDW with DR. Methods: This study was an explanatory, observational study with cross-sectional design of T2DM patients treated at the Endocrinology, Metabolic and Diabetes Outpatient Clinic at Dr. Soetomo General Hospital, Surabaya, Indonesia, from July 2019 to December 2019. Results: A total of 179 subjects consisted of 80 males (44.7%) and 99 females (55.3%), with a mean age of 54.79±9.37 years. The Non-Diabetic Retinopathy were in 49 subjects (27,4%), Non Proliferative Diabetic Retinopathy (NPDR) were in 86 subjects (48.0%), and Proliferative Diabetic Retinopathy (PDR) were in 44 subjects (24.6%). The mean levels of MPV and PDW were 10.44±1.10 fL and 10.76±1.76 fL, respectively. There was a significant relationship between MPV (p <0.0001, OR=16.088, 95% CI: 5.323-48.622) and PDW (p = 0.012, OR=2.475 95% CI: 1.067-5.743) with PDR. Conclusion: MPV and PDW were associated with the occurence of PDR.
Keyword: Diabetic Retinopathy (DR), Mean Platelet Volume (MPV), Platelet Distribution Width (PDW)
DOI: https://doi.org/10.31838/ijpr/2020.12.04.221
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