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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Application of Purple Leaf Extract (Graptophyllum Pictum) In Wound Healing Process of Collagen Density

Author: MUHAMMAD BRAHMANTYO, INTAN NIRWANA, DAN DEVI RIANTI
Abstract: Background: Purple leaves are derived from the Graptophyllum pictum plant, the Acanthacea family contains: flavonoids, saponins, and tannins. Purple leaf extract has anti-inflammatory and analgesic effects. Purpose: This study observed an increase in the density of collagen in wounds in wistar rats. Methods: The research subjects were 24 adult and healthy Wistar (Rattus norvegicus) mice, aged 3 months, with a body weight of 200 grams, which were divided into 6 groups of 4 rats each. The making of purple leaf extract is as follows, purple leaf powder weighed as much as 500 grams, then moistened with 96% ethanol as much as 500 ml. Research data were analyzed using the Kruskall Wallis and Mann Whitney tests. Results: Statistical data analysis using the Kruskall Wallis test showed significant differences in collagen density (P<0.005). Conclusion: Giving a 15% purple leaf extract gel increases collagen density.
Keyword: Purple leaf (Graptophyllum pictum), wound healing, incision, collagen.
DOI: https://doi.org/10.31838/ijpr/2020.12.04.218
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