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Association of Initial Vitamin D Level with CD4 Cell Count Changes in HIV-Naïve Patients Receiving Antiretroviral Therapy
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| Author:
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ROSITA BASKORO, USMAN HADI, MUSOFA RUSLI
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| Abstract:
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Background: Various studies have reported an association between vitamin D and CD4 levels. On the other hand, there are studies reporting the use of antiretroviral (ARV) drugs which will reduce vitamin D level. This study aimed to analyze the correlation of initial vitamin D level with changes of CD4 cells count after 3 months of ARV therapy in HIV naïve adult patients.
Methods: This was a cohort study of HIV naïve patients who had never received ARV therapy. All study subjects were examined for 25(OH)D levels and CD4 cell count from serum blood before and after receiving ARV therapy for 3 months.
Results: Among 24 subjects, 67% were male, with median age of 30 years, and 71% were at stage 1 HIV. There were no significant differences in levels of 25(OH)D after 3 months of ARV therapy (p = 0.275) with mean initial 25(OH)D levels of 20.48±3.18 ng/ml and after 3 months of ARV therapy of 19.78±4.47 ng/ml. A significant moderate correlation was found between initial 25(OH)D level and changes in CD4 cells count (r = 0.407, p = 0.048).
Conclusions : Initial 25(OH)D level is associated with CD4 cells count changes after 3 months of ARV therapy in HIV naïve adult patients.
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| Keyword:
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HIV, CD4, ARV, Vitamin D, 25(OH)D.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.211
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| Download:
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Request For Article
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